SCHEMBL31004064

SCHEMBL31004064

Fc1c(Nc2ncnc3cc4c(cc23)OCCO4)cccc1C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 1.00
ABL1 P00519 1/20 0.55
PDGFRB P09619 1/20 0.55
FGFR1 P11362 1/20 0.55
SRC P12931 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20865217 1.00 EGFR (1.00) EGFRABL1PDGFRBFGFR1SRC
SCHEMBL20865297 0.86 EGFR (1.00) EGFRABL1PDGFRBFGFR1SRC
SCHEMBL20865303 0.84 EGFR (1.00) EGFR
SCHEMBL29363644 0.84 EGFR (1.00) EGFR
SCHEMBL20865211 0.84 EGFR (1.00) EGFR
SCHEMBL20865372 0.84 EGFR (1.00) EGFRABL1PDGFRBFGFR1SRC
SCHEMBL22427546 0.84 EGFR (0.78) EGFRABL1PDGFRBFGFR1SRC
SCHEMBL31004070 0.84 EGFR (1.00) EGFR
SCHEMBL20865216 0.83 EGFR (1.00) EGFR
SCHEMBL31004065 0.83 EGFR (1.00) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118459413-A Compositions and methods for treating cancer 加利福尼亚大学董事会 2024-08-09 CN disclosed