Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009432 | 0.81 | HPGD (0.69) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL13753553 | 0.81 | RXFP1 (0.60) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL13753526 | 0.80 | HPGD (0.68) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL27424708 | 0.79 | HPGD (0.54) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL16169924 | 0.78 | GAA (0.59) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL13761333 | 0.77 | HPGD (0.51) | MEN1KMT2AHPGDGAAPOLB | |
| SCHEMBL13753558 | 0.77 | HPGD (0.51) | MEN1KMT2AHPGDGAAPOLB | |
| SCHEMBL21697075 | 0.75 | GAA (0.59) | MEN1KMT2AHPGDGAAMAPK1 | |
| SCHEMBL22054772 | 0.75 | GAA (0.59) | MEN1KMT2AHPGDGAAMAPK1 | |
| SCHEMBL20370207 | 0.74 | GAA (0.76) | KMT2AHPGDGAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638424-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024137813-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |