SCHEMBL31008752

SCHEMBL31008752

CCC(=O)Cn1c(=O)n(Cc2ccc(OC)cc2)c2ncc(-c3ccc(F)c(F)c3)cc21

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 20/20 0.68
GRIN1 Q05586 19/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31008684 0.87 GRIN1 (0.70) GRIN2BGRIN1
SCHEMBL28736487 0.87 GRIN1 (0.70) GRIN2BGRIN1
SCHEMBL29636007 0.82 PDE1B (0.55) GRIN2BGRIN1
SCHEMBL28736421 0.82 PDE1B (0.55) GRIN2BGRIN1
SCHEMBL20130122 0.82 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL20130121 0.74 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL29635431 0.74 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL20134318 0.71 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL28736409 0.71 GRIN2B (0.58) GRIN2BGRIN1
SCHEMBL29636149 0.71 GRIN2B (0.58) GRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114989164-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2024-08-13 CN disclosed