Pyridine

Pyridine

SCHEMBL3101129

O=C(O)c1ncccn1.c1ccncc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 6/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
LMNA P02545 2/20 0.48
P4HTM Q9NXG6 1/20 0.48
TDP1 Q9NUW8 2/20 0.45
TSHR P16473 2/20 0.45
P2RX7 Q99572 1/20 0.43
KDM4E B2RXH2 5/20 0.41
ALDH1A1 P00352 3/20 0.41
HCAR2 Q8TDS4 2/20 0.41
APP P05067 1/20 0.41
GAA P10253 1/20 0.41
HCAR3 P49019 1/20 0.41
CTNNB1 P35222 1/20 0.41
WNT3A P56704 1/20 0.41
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
ALOX15 P16050 1/20 0.40
BLM P54132 1/20 0.40
AGER Q15109 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27677548 0.89 NAPRT (0.50) NAPRTL3MBTL1LMNAP4HTMTDP1
SCHEMBL108190 0.89
Pyrimidine SCHEMBL30350063 0.88 NAPRT (0.41) NAPRTL3MBTL1LMNAP4HTMTDP1
SCHEMBL27936995 0.87 NAPRT (0.48) NAPRTL3MBTL1LMNAP4HTMTDP1
SCHEMBL27638967 0.87 NAPRT (0.48) NAPRTL3MBTL1LMNAP4HTMTDP1
SCHEMBL27821532 0.87 NAPRT (0.48) NAPRTL3MBTL1LMNAP4HTMTDP1
Bromide SCHEMBL5264768 0.87 NAPRT (0.48) NAPRTL3MBTL1LMNAP4HTMTDP1
Hydrochloric Acid SCHEMBL2553231 0.87 NAPRT (0.48) NAPRTL3MBTL1LMNAP4HTMTDP1
Formaldehyde SCHEMBL27710889 0.84 NAPRT (0.46) NAPRTL3MBTL1LMNAP4HTMTDP1
Hydrazine SCHEMBL27868318 0.84 P2RX7 (0.52) NAPRTL3MBTL1LMNAP4HTMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803791-B2 Method for producing albumin conjugates containing gyrase inhibitors ALBUPHARM HEIDELBERG GMBH & CO. KG (DE) 2010-09-28 US claimed
EP-1841792-B1 METHOD FOR PRODUCING ALBUMIN CONJUGATES CONTAINING GYRASE INHIBITORS ALBUPHARM HEIDELBERG GMBH & CO (DE) 2010-03-03 EP claimed
US-20080108708-A1 Method for Producing Albumin Conjugates Containing Gyrase Inhibitors ALBUPHARM HEIDELBERG GMBH & CO. KG (DE) 2008-05-08 US claimed
JP-54081298-A None JP disclosed
JP-52151195-A None JP disclosed
JP-58085887-A None JP disclosed
US-7803791-B2 Method for producing albumin conjugates containing gyrase inhibitors ALBUPHARM HEIDELBERG GMBH & CO. KG (DE) 2010-09-28 US disclosed
US-20080108708-A1 Method for Producing Albumin Conjugates Containing Gyrase Inhibitors ALBUPHARM HEIDELBERG GMBH & CO. KG (DE) 2008-05-08 US disclosed
EP-0312794-B1 THIAZETIDINE DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1993-05-19 EP disclosed
US-5015636-A Bactericides NIPPON SHINYAKU CO., LTD. (JP) 1991-05-14 US disclosed
US-4882328-A ANTIBACTERIAL NIPPON SHINYAKU CO. LTD. (JP) 1989-11-21 US disclosed
EP-0312794-A1 Thiazetidine derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1989-04-26 EP disclosed
JP-S5885887-A PREPARATION OF PYRIDOPYRIMIDINECARBOXYLIC ACID MITSUI PETROCHEM IND LTD 1983-05-23 JP disclosed
JP-S5481298-A PREPARATION OF PYRIDOPYRIMIDINECARBOXYLIC ACID DERIVATIVE DAITO KOEKI KK 1979-06-28 JP disclosed
US-4103011-A BACTERICIDES DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1978-07-25 US disclosed
JP-S52151195-A PREPARATION OF PYRIDOPYRIMIDINE CARBOXYLIC ACID DERIVATIVES TEIJIN LTD 1977-12-15 JP disclosed