Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31020122 | 0.90 | USP30 (0.43) | RXRARXRBRXRGCCNT1CCNA2 | |
| SCHEMBL31020042 | 0.88 | IL1B (0.38) | SYK | |
| SCHEMBL31020113 | 0.79 | IL1B (0.50) | RXRARXRBRXRGBTK | |
| SCHEMBL31020047 | 0.78 | PRMT5 (0.45) | RXRARXRBRXRGCCNT1CCNA2 | |
| SCHEMBL31020065 | 0.77 | IL1B (0.40) | RXRARXRBRXRGBTK | |
| SCHEMBL31020067 | 0.76 | HTR2C (0.41) | RXRARXRBRXRGBTK | |
| SCHEMBL31020044 | 0.76 | IL1B (0.39) | RXRARXRBRXRGBTK | |
| SCHEMBL30080156 | 0.75 | NSD2 (0.37) | SYKRORC | |
| SCHEMBL31020078 | 0.73 | IL1B (0.50) | — | |
| SCHEMBL31020095 | 0.73 | IL1B (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658653-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINES AS NLRP3 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160692-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINES AS NLRP3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-08-08 | — | — | WO | disclosed |