Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.77 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.56 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.50 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.50 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | PRKCG | P05129 | 2/20 | 0.48 |
| ▸ | PRKCB | P05771 | 2/20 | 0.48 |
| ▸ | PRKCA | P17252 | 2/20 | 0.48 |
| ▸ | PRKCH | P24723 | 2/20 | 0.48 |
| ▸ | PRKCI | P41743 | 2/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL31275303 | 0.89 | LPAR5 (0.60) | LPAR5USP2PRKD3PRKCGPRKCB | |
| Choline SCHEMBL28269647 | 0.89 | LPAR5 (0.59) | LPAR5USP2PRKD3PRKCGPRKCB | |
| Choline SCHEMBL28329713 | 0.89 | LPAR5 (0.59) | LPAR5USP2PRKD3PRKCGPRKCB | |
| Alcohol SCHEMBL27989503 | 0.88 | LPAR5 (0.94) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL258094 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL258032 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL7829804 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL7820593 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL12621099 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 | |
| SCHEMBL258118 | 0.88 | LPAR5 (1.00) | LPAR5LPAR3LPAR1LPAR2LPAR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118647369-A | Ionizable lipids containing biodegradable disulfide bonds and lipid nanoparticles comprising same | ST制药株式会社 | 2024-09-13 | — | — | CN | claimed |
| CN-118632690-A | Ionizable lipids containing biodegradable ester linkages and lipid nanoparticles comprising same | ST制药株式会社 | 2024-09-10 | — | — | CN | claimed |