Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL310926 | 0.87 | CHEK1 (0.46) | CHEK1ALDH1A1TDP1LMNA | |
| SCHEMBL2955866 | 0.86 | CHEK1 (0.46) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| SCHEMBL10258010 | 0.86 | CHEK1 (0.46) | CHEK1ALDH1A1TDP1LMNA | |
| Iodide SCHEMBL2203284 | 0.85 | ABCB1 (0.46) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| SCHEMBL12428994 | 0.84 | CHEK1 (0.45) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| SCHEMBL12428999 | 0.82 | CHEK1 (0.43) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| Bromide SCHEMBL2205235 | 0.81 | CHEK1 (0.43) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| Iodide SCHEMBL2207995 | 0.76 | ABCB1 (0.48) | ABCB1ALDH1A1TDP1ABCC1LMNA | |
| SCHEMBL11224598 | 0.75 | CHEK1 (0.61) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| SCHEMBL12429002 | 0.74 | ABCB1 (0.46) | ABCB1ALDH1A1TDP1ABCC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162454-B1 | IMIDAZOPYRIDINE KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| US-8093239-B2 | Imidazopyridine kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100216779-A1 | Imidazopyridine Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2010-08-26 | — | — | US | disclosed |
| EP-2162454-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150799-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |
| US-20080300242-A1 | Imidazopyridine Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300242-A1 | Imidazopyridine Kinase Inhibitors | ABL1, MAP3K19, MAP3K5 | CHEK1 240/4885ABCB1 683/4885ALDH1A1 3410/4885 |
| US-20100216779-A1 | Imidazopyridine Kinase Inhibitors | ABL1, MAP3K19, MAP3K5 | CHEK1 240/4885ABCB1 683/4885ALDH1A1 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.