Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2203284 | 0.99 | ABCB1 (0.46) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| SCHEMBL12429002 | 0.91 | ABCB1 (0.46) | ABCB1ALDH1A1TDP1ABCC1LMNA | |
| SCHEMBL2955866 | 0.90 | CHEK1 (0.46) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| Iodide SCHEMBL2207995 | 0.89 | ABCB1 (0.48) | ABCB1ALDH1A1TDP1ABCC1LMNA | |
| SCHEMBL10266656 | 0.86 | CHEK1 (0.47) | CHEK1ABCB1ALDH1A1TDP1LMNA | |
| Iodide SCHEMBL309744 | 0.85 | CHEK1 (0.47) | CHEK1ABCB1ALDH1A1TDP1LMNA | |
| SCHEMBL12428988 | 0.84 | MAPT (0.38) | ABCB1ALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL12428999 | 0.84 | CHEK1 (0.43) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| Iodide SCHEMBL310215 | 0.84 | CHEK1 (0.43) | CHEK1ABCB1ALDH1A1TDP1ABCC1 | |
| Iodide SCHEMBL2209494 | 0.83 | MAPT (0.38) | ABCB1ALDH1A1LMNAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981903-B2 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20100204196-A1 | 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer | GLAXOSMITHKLINE LLC | 2010-08-12 | — | — | US | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204196-A1 | 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer | IGF1R, IGFBP2, IGFBP1 | CHEK1 477/4885ABCB1 2297/4885ALDH1A1 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.