Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL31025166

CC(Cn1c(=S)[nH]c(=O)c2[nH]cnc21)NCc1ccc(C(F)(F)F)nc1.O=C(O)C(F)(F)F

nearest known ligand 0.47

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 6/20 0.47
TPO P07202 4/20 0.47
CYP3A4 P08684 2/20 0.39
KCNH2 Q12809 1/20 0.39
PNP P00491 1/20 0.36
PDE4A P27815 2/20 0.34
ADORA2A P29274 2/20 0.34
PDE4B Q07343 2/20 0.34
PDE4C Q08493 2/20 0.34
PDE4D Q08499 2/20 0.34
PTGES O14684 3/20 0.34
CYP2C9 P11712 2/20 0.34
DAO P14920 1/20 0.33
CYP2C8 P10632 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
HPGD P15428 1/20 0.33
ADORA2B P29275 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL2283491 1.00 MPO (0.47) MPOTPOCYP3A4KCNH2PNP
SCHEMBL3128366 0.95 MPO (0.51) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL2284280 0.90 MPO (0.48) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL2283914 0.82 MPO (0.52) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL31025210 0.82 MPO (0.52) MPOTPOCYP3A4KCNH2PNP
SCHEMBL4041168 0.82 MPO (0.53) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL31025175 0.79 MPO (0.49) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL2286362 0.79 MPO (0.49) MPOTPOCYP3A4KCNH2PNP
Trifluoroacetic Acid SCHEMBL2281263 0.78 MPO (0.47) MPOTPOCYP3A4KCNH2PNP
SCHEMBL2281089 0.78 MPO (0.56) MPOTPOCYP3A4KCNH2PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024163892-A9 MYELOPEROXIDASE (MPO) INHIBITION AS A TREATMENT TARGET FOR DELAYED CEREBRAL INJURY (DCI) IN ANEURYSMAL SUBARACHNOID HEMORRHAGE (SAH) UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2025-01-16 WO disclosed
WO-2024163892-A1 MYELOPEROXIDASE (MPO) INHIBITION AS A TREATMENT TARGET FOR DELAYED CEREBRAL INJURY (DCI) IN ANEURYSMAL SUBARACHNOID HEMORRHAGE (SAH) UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2024-08-08 WO disclosed