Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.61 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 5/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22345825 | 1.00 | IKZF2 (0.61) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL27241633 | 0.90 | IKZF2 (0.53) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL22345864 | 0.90 | IKZF2 (0.62) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL19585928 | 0.90 | CRBN (0.57) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL25133737 | 0.88 | IKZF2 (0.49) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL25133738 | 0.88 | IKZF2 (0.51) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL29927258 | 0.87 | CRBN (0.51) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL20231931 | 0.87 | CRBN (0.51) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL21680375 | 0.86 | CRBN (0.45) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL31442786 | 0.86 | DDB1 (0.49) | IKZF2CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024162746-A1 | INDOLE COMPOUND DECOMPOSING IKZF2, AND USE THEREOF | 한국화학연구원 | 2024-08-08 | — | — | WO | disclosed |