Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.62 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.62 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31025903 | 0.90 | IKZF2 (0.61) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL22345825 | 0.90 | IKZF2 (0.61) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL19585928 | 0.90 | CRBN (0.57) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL20234415 | 0.87 | CRBN (0.51) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL22581128 | 0.84 | IKZF2 (0.48) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL30023739 | 0.84 | IKZF2 (0.48) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL21680375 | 0.83 | CRBN (0.45) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL22581089 | 0.82 | IKZF2 (0.56) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL31129758 | 0.82 | IKZF2 (0.56) | IKZF2IKZF1CRBNDDB1IKZF3 | |
| SCHEMBL24406575 | 0.82 | CRBN (0.47) | IKZF2IKZF1CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479817-B2 | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof | NOVARTIS AG (CH) | 2025-11-25 | — | — | US | disclosed |
| US-20220144798-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2022-05-12 | — | — | US | disclosed |
| EP-3924055-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2021-12-22 | — | — | EP | disclosed |
| CN-113329792-A | Substituted 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2021-08-31 | — | — | CN | disclosed |
| WO-2020165834-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12479817-B2 | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof | XDH, RXFP3, NPY2R | IKZF2 4560/4885IKZF1 3715/4885CRBN 3673/4885 |
| US-20220144798-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | XDH, RXFP3, NPY2R | IKZF2 4560/4885IKZF1 3715/4885CRBN 3673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.