⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31099334 | 0.83 | — | — | |
| SCHEMBL819489 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL14741222 | 0.70 | EGLN1 (0.37) | — | |
| SCHEMBL29434696 | 0.64 | — | — | |
| SCHEMBL1017667 | 0.60 | — | — | |
| SCHEMBL28180462 | 0.60 | — | — | |
| SCHEMBL31120428 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL1017781 | 0.59 | — | — | |
| SCHEMBL9234298 | 0.59 | — | — | |
| SCHEMBL15049363 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074902-A1 | FUSED BICYCLIC HETEROARYL AMIDE COMPOUND AS PROTEIN AGGREGATION INHIBITOR | SHANGHAI JINGXIN BIOMEDICAL CO., LTD. (CN) | 2025-03-06 | — | — | US | disclosed |
| WO-2025002040-A1 | CRYSTAL FORM OR SALT OF BICYCLIC HETEROARYL AMIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海京新生物医药有限公司 | 2025-01-02 | — | — | WO | disclosed |
| EP-4458824-A1 | FUSED BICYCLIC HETEROARYL AMIDE COMPOUND AS PROTEIN AGGREGATION INHIBITOR | Shanghai Jingxin Biomedical Co., Ltd. (CN) | 2024-11-06 | — | — | EP | disclosed |
| CN-118488951-A | Fused bicyclic heteroaryl amide compounds as inhibitors of protein aggregation | 上海京新生物医药有限公司 | 2024-08-13 | — | — | CN | disclosed |