SCHEMBL31026652

SCHEMBL31026652

COc1nc(Cl)c(F)c2nc(SC)nc(N)c12

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 0.34
L3MBTL1 Q9Y468 3/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
RECQL P46063 1/20 0.32
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25247825 0.87 L3MBTL1 (0.36) L3MBTL1KMT2AMEN1ALDH1A1MAPT
SCHEMBL27138690 0.83 L3MBTL1 (0.32) L3MBTL1KMT2AMEN1ALDH1A1MAPT
SCHEMBL31662105 0.81 ABCB1 (0.31) ABCB1
SCHEMBL30835179 0.80 ABCB1 (0.35) ABCB1
SCHEMBL30610877 0.78 PDCD1 (0.31)
SCHEMBL30702944 0.78
SCHEMBL30702909 0.78 FYN (0.35) KMT2AMEN1ALDH1A1MAPTLMNA
SCHEMBL25401576 0.77 SRC (0.39) KMT2AMEN1ALDH1A1MAPTRECQL
SCHEMBL26709320 0.77 ABCB1 (0.33) ABCB1
SCHEMBL26709236 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151594-A1 FUSED AZINES AS RAS INHIBITORS AND METHODS OF USE THEREOF KESTREL THERAPEUTICS INC. (US) 2025-07-17 WO disclosed
CN-118221700-A Condensed ring aromatic compound, preparation method and application thereof 北京华森英诺生物科技有限公司 2024-06-21 CN disclosed