Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.76 |
| ▸ | RAB9A | P51151 | 7/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | EPHB3 | P54753 | 6/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172077 | 0.88 | HTT (0.67) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6121120 | 0.81 | NPC1 (0.63) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3085478 | 0.81 | EPHB3 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL416200 | 0.80 | EPHB3 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL22170113 | 0.80 | EPHB3 (1.00) | NPC1RAB9AEPHB3RIPK2LCK | |
| Hydrochloric Acid SCHEMBL30152645 | 0.79 | EPHB3 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL19119427 | 0.79 | EPHB3 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1286674 | 0.79 | NPC1 (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL9282686 | 0.79 | ALDH1A1 (0.66) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15210511 | 0.78 | HTT (0.79) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626884-A1 | N-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXAMIDE DERIVATIVES AS WILD TYPE C-KIT KINASE INHIBITORS FOR THE TREATMENT OF URTICARIA | Blueprint Medicines Corporation (US) | 2025-10-08 | — | — | EP | disclosed |
| CN-120677154-A | N-phenyl-pyrazolo [1,5-a ] pyridine-3-carboxamide derivatives as wild-type C-KIT kinase inhibitors for the treatment of urticaria | 缆图药品公司 | 2025-09-19 | — | — | CN | disclosed |
| WO-2024118887-A1 | N-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXAMIDE DERIVATIVES AS WILD TYPE C-KIT KINASE INHIBITORS FOR THE TREATMENT OF URTICARIA | BLUEPRINT MEDICINES CORPORATION (US) | 2024-06-06 | — | — | WO | disclosed |