SCHEMBL31028149

SCHEMBL31028149

O=C(O)c1ccc(CNC(=O)c2cc(-c3ccncc3)ccc2Oc2ccc(F)cc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.76
PTGER2 P43116 2/20 0.76
MAPK14 Q16539 5/20 0.58
CYP3A4 P08684 3/20 0.58
L3MBTL1 Q9Y468 1/20 0.50
MMP13 P45452 2/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ROCK2 O75116 1/20 0.48
RPS6KA5 O75582 1/20 0.48
MAP4K4 O95819 1/20 0.48
PRKCG P05129 1/20 0.48
PRKACA P17612 1/20 0.48
RPS6KB1 P23443 1/20 0.48
MAPK1 P28482 1/20 0.48
AKT1 P31749 1/20 0.48
GSK3A P49840 1/20 0.48
GSK3B P49841 1/20 0.48
PRKX P51817 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22319348 1.00 PTGER4 (0.76) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL22319352 0.96 PTGER4 (0.70) PTGER4PTGER2MAPK14CYP3A4MMP13
SCHEMBL22319379 0.94 PTGER4 (0.85) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL31028174 0.94 PTGER4 (0.85) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL22319351 0.91 PTGER4 (0.80) PTGER4PTGER2L3MBTL1LMNAHTT
SCHEMBL22319390 0.90 PTGER4 (0.61) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL22319356 0.89 PTGER4 (0.74) PTGER4PTGER2MAPK14CYP3A4PPARG
SCHEMBL22319376 0.89 PTGER4 (0.74) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL31028151 0.89 PTGER4 (0.74) PTGER4PTGER2MAPK14CYP3A4L3MBTL1
SCHEMBL22319397 0.89 PTGER4 (0.85) PTGER4PTGER2MAPK14CYP3A4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113646299-B Novel N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2 (PGE 2) receptor modulators 梅迪比奥法尔玛公司 2024-07-26 CN claimed
CN-113646299-B Novel N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2 (PGE 2) receptor modulators 梅迪比奥法尔玛公司 2024-07-26 CN disclosed