Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254138 | 0.85 | TUBB4A (0.60) | FFAR1SRCEPHX2AURKBKDM1A | |
| SCHEMBL13096850 | 0.83 | HRH3 (0.47) | RETSRCPPARGEPHX2ACACB | |
| SCHEMBL12782506 | 0.83 | SRC (0.56) | FFAR1SRCEPHX2AURKB | |
| SCHEMBL11917498 | 0.83 | SRC (0.66) | FFAR1SRCEPHX2AURKB | |
| SCHEMBL3103187 | 0.82 | SRC (0.44) | RETFFAR1SRCEPHX2ALDH1A1 | |
| SCHEMBL25380162 | 0.80 | KDM1A (0.60) | PPARGEPHX2GAASMN1; SMN2KDM4E | |
| SCHEMBL7400266 | 0.80 | GAA (0.62) | EPHX2GAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10297946 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL13096968 | 0.79 | HRH3 (0.41) | RETFFAR1PPARGGAASMN1; SMN2 | |
| SCHEMBL13096969 | 0.79 | HRH3 (0.40) | RETFFAR1PPARGEPHX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256147-A1 | BIARYL ACETAMIDE DERIVATIVES AS MODULATORS OF THE KINASE CASCADE FOR THE TREATMENT OF HEARING LOSS, OSTEOPOROSIS AND CELL PROLIFERATION DISORDERS | KINEX PHARMACEUTICALS, LLC | 2010-10-07 | — | — | US | disclosed |
| WO-2008127727-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256147-A1 | BIARYL ACETAMIDE DERIVATIVES AS MODULATORS OF THE KINASE CASCADE FOR THE TREATMENT OF HEARING LOSS, OSTEOPOROSIS AND CELL PROLIFERATION DISORDERS | BMP2K, MAP3K2, MAP3K6 | RET 643/4885FFAR1 3553/4885SRC 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.