Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31032103 | 0.85 | NPC1 (0.57) | EGFRPARP1MCL1ARNPC1 | |
| SCHEMBL19520186 | 0.79 | PARP1 (0.47) | PARP1NPC1RAB9AMKNK2MKNK1 | |
| SCHEMBL31032076 | 0.78 | PARP1 (0.44) | PARP1MCL1ARSYK | |
| SCHEMBL31032063 | 0.78 | PARP1 (0.51) | EGFRPARP1MKNK2KMT2APLK4 | |
| SCHEMBL31032045 | 0.77 | PARP1 (0.50) | EGFRPARP1MCL1NPC1POLB | |
| SCHEMBL30108283 | 0.77 | PARP1 (0.50) | EGFRPARP1MCL1NPC1POLB | |
| SCHEMBL4936429 | 0.77 | PARP1 (0.50) | EGFRPARP1MCL1NPC1POLB | |
| SCHEMBL27893740 | 0.75 | PIK3CD (0.54) | PIK3CDPIK3CAEGFRTDO2AR | |
| SCHEMBL30627398 | 0.74 | TGFBR1 (0.50) | PARP1ARSYKPLK4MAP4K4 | |
| SCHEMBL7572389 | 0.74 | TGFBR1 (0.50) | PARP1ARSYKPLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287080-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED (GB) | 2024-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287080-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLK, POLB | PIK3CD 116/4885PIK3CA 189/4885EGFR 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.