Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 8/20 | 0.49 |
| ▸ | BCR | P11274 | 8/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.47 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.47 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922195 | 0.86 | PDPK1 (0.53) | PDPK1JAK2ABL1BCRMAP2K4 | |
| SCHEMBL28258656 | 0.86 | CHEK1 (0.53) | CHEK1JAK2MAP2K4MAPK1MAPKAPK2 | |
| SCHEMBL19773425 | 0.84 | CHEK1 (0.52) | CHEK1JAK2MAP2K4MAPK1MAPKAPK2 | |
| SCHEMBL4404646 | 0.84 | PDPK1 (0.51) | PDPK1JAK2ABL1BCRJAK1 | |
| Hydrochloric Acid SCHEMBL17205412 | 0.84 | PDPK1 (0.51) | PDPK1JAK2ABL1BCRMAP2K4 | |
| SCHEMBL31173858 | 0.83 | MAP2K4 (0.51) | CHEK1JAK2ABL1BCRMAP2K4 | |
| SCHEMBL5051796 | 0.83 | CHEK1 (0.54) | CHEK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL25139495 | 0.80 | ABL1 (0.51) | PDPK1JAK2ABL1BCRJAK1 | |
| SCHEMBL4404846 | 0.80 | MAP2K4 (0.56) | PDPK1JAK2ABL1BCRMAP2K4 | |
| SCHEMBL30159687 | 0.80 | MAP2K4 (0.56) | PDPK1JAK2ABL1BCRMAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024178219-A1 | 1-ACYL-3-AMINOINDAZOLES FOR TREATING CYSTIC FIBROSIS | SHOICHET BRIAN (US) | 2024-08-29 | — | — | WO | disclosed |