Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 9/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21713091 | 1.00 | KLKB1 (0.36) | KLKB1PDE10AMEN1GFERKMT2A | |
| SCHEMBL23769652 | 0.85 | PDE10A (0.30) | PDE10A | |
| SCHEMBL23769213 | 0.84 | TRIM24 (0.33) | PDE10A | |
| SCHEMBL23769662 | 0.84 | ALDH1A1 (0.33) | PDE10AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23754062 | 0.83 | KLKB1 (0.32) | KLKB1 | |
| SCHEMBL23843164 | 0.81 | KLKB1 (0.37) | KLKB1PDE10AKDM4EALDH1A1GAA | |
| SCHEMBL23769542 | 0.81 | KLKB1 (0.42) | KLKB1 | |
| SCHEMBL26308009 | 0.81 | KLKB1 (0.35) | KLKB1 | |
| SCHEMBL21712992 | 0.80 | SMPD3 (0.39) | KLKB1PDE10A | |
| SCHEMBL26311956 | 0.79 | KLKB1 (0.44) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120287-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-113039181-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2024-08-13 | — | — | CN | disclosed |