Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5874024 | 1.00 | PNMT (0.56) | PNMTADRA2ALMNAHTTMEN1 | |
| SCHEMBL6682373 | 0.91 | PNMT (0.50) | PNMTADRA2ALMNAHTTMEN1 | |
| SCHEMBL5435437 | 0.89 | PNMT (0.50) | PNMTADRA2ALMNAHTTMEN1 | |
| SCHEMBL31357961 | 0.88 | PNMT (0.56) | PNMTADRA2ALMNAHTTMEN1 | |
| SCHEMBL29310335 | 0.88 | PNMT (0.56) | PNMTADRA2ALMNAHTTMEN1 | |
| SCHEMBL6294929 | 0.83 | PNMT (0.58) | PNMTADRA2AMEN1KMT2ACYP19A1 | |
| SCHEMBL24773896 | 0.81 | PNMT (0.56) | PNMTADRA2ACYP19A1HTR2AHTR2C | |
| SCHEMBL25031178 | 0.78 | PNMT (0.52) | PNMTADRA2ACYP19A1HTR2AHTR2C | |
| SCHEMBL24774365 | 0.78 | PNMT (0.52) | PNMTADRA2ALMNAHTTCYP19A1 | |
| SCHEMBL31034861 | 0.78 | PNMT (0.52) | PNMTADRA2ACYP19A1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118434729-A | Fused ring compounds as HPK1 inhibitors | 微境生物医药科技(上海)有限公司 | 2024-08-02 | — | — | CN | disclosed |