Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | WEE1 | P30291 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633986 | 1.00 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL8967453 | 1.00 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL28249127 | 1.00 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL7403092 | 0.98 | KDM4E (0.42) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL6598413 | 0.94 | KDM4E (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL11015946 | 0.92 | GSK3B (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL10914947 | 0.92 | GSK3B (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL10712855 | 0.92 | GSK3B (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL11206986 | 0.92 | GSK3B (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL1424202 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255685-A | Tricyclic compound, pharmaceutical composition and application thereof | 珂阑(上海)医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |