Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31037912 | 1.00 | PARP10 (0.35) | PARP10PARP11NISCHKDM4EHSD17B10 | |
| SCHEMBL31546236 | 0.95 | PARP10 (0.34) | PARP10PARP11NISCHKDM4EHSD17B10 | |
| SCHEMBL31546222 | 0.95 | PARP10 (0.34) | PARP10PARP11NISCHKDM4EHSD17B10 | |
| SCHEMBL10885068 | 0.78 | MAPT (0.35) | NISCHKDM4EHSD17B10DYRK1ACLK4 | |
| SCHEMBL10885072 | 0.78 | MAPT (0.35) | NISCHKDM4EHSD17B10DYRK1ACLK4 | |
| SCHEMBL11251790 | 0.77 | PARP10 (0.33) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL4716982 | 0.72 | PARP10 (0.35) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL10896436 | 0.71 | MAPT (0.43) | NISCHKDM4ELRRK2 | |
| SCHEMBL11651390 | 0.71 | MAPT (0.43) | NISCHKDM4ELRRK2 | |
| SCHEMBL31546240 | 0.68 | HTR1A (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119731163-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-118666851-A | Condensed ring KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-09-20 | — | — | CN | disclosed |