Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546213 | 0.98 | POLB (0.50) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL31037904 | 0.94 | POLB (0.44) | POLBHPGDMEN1KMT2AMAPT | |
| SCHEMBL31037908 | 0.81 | POLB (0.52) | POLBMEN1KMT2AHDAC6MAPT | |
| SCHEMBL8969481 | 0.80 | ACHE (0.50) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL31546226 | 0.79 | POLB (0.50) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL8968919 | 0.78 | ACHE (0.48) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL8969167 | 0.75 | NPC1 (0.49) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL18148653 | 0.74 | POLB (0.44) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30842164 | 0.74 | POLB (0.44) | POLBHPGDMEN1KMT2AHDAC6 | |
| SCHEMBL10830714 | 0.73 | MEN1 (0.62) | POLBHPGDMEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119731163-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-118666851-A | Condensed ring KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-09-20 | — | — | CN | disclosed |