Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.54 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717008 | 0.91 | CA1 (0.58) | CA1CA2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL26911126 | 0.88 | CYP2C19 (0.62) | CA1CA2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL23484836 | 0.86 | CYP2C19 (0.60) | CA1CA2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL6059390 | 0.85 | CA1 (0.63) | CA1CA2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL3920855 | 0.83 | CA1 (0.59) | CA1CA2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL6248458 | 0.83 | LMNA (0.68) | CA1CA2KDM4ESMN1; SMN2STIM1 | |
| SCHEMBL10993825 | 0.83 | SMN1; SMN2 (0.64) | CA1CA2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2744548 | 0.83 | CA1 (0.59) | CA1CA2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL2555397 | 0.82 | MAPT (0.48) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL17493532 | 0.81 | FFAR1 (0.53) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118843613-A | RXFP1 agonists | 百时美施贵宝公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118414330-A | Naphthalene and quinoline analogs as RXFP1 agonists | 百时美施贵宝公司 | 2024-07-30 | — | — | CN | disclosed |