Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 14/20 | 0.82 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039756 | 1.00 | NLRP3 (0.82) | NLRP3JAK3JAK2JAK1MAPK10 | |
| SCHEMBL27292600 | 0.95 | NLRP3 (0.83) | NLRP3JAK3JAK2JAK1MAPK10 | |
| SCHEMBL31039752 | 0.95 | NLRP3 (0.83) | NLRP3JAK3JAK2JAK1MAPK10 | |
| SCHEMBL31039768 | 0.95 | NLRP3 (0.83) | NLRP3JAK3JAK2JAK1MAPK10 | |
| SCHEMBL27292424 | 0.90 | NLRP3 (1.00) | NLRP3 | |
| SCHEMBL31039686 | 0.90 | NLRP3 (1.00) | NLRP3 | |
| SCHEMBL27292480 | 0.89 | NLRP3 (1.00) | NLRP3 | |
| SCHEMBL31039682 | 0.89 | NLRP3 (1.00) | NLRP3 | |
| SCHEMBL30055311 | 0.89 | NLRP3 (0.84) | NLRP3 | |
| SCHEMBL27204026 | 0.89 | NLRP3 (0.84) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630417-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. Hoffmann-La Roche AG (CH) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024121086-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. HOFFMANN-LA ROCHE AG (CH) | 2024-06-13 | — | — | WO | disclosed |