Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391671 | 1.00 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3492339 | 0.88 | NPC1 (0.81) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL30622710 | 0.80 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL24653524 | 0.80 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1395948 | 0.76 | GSK3B (0.55) | NPC1RAB9AKDM4EMAPTGSK3B | |
| SCHEMBL10225785 | 0.76 | NPC1 (0.60) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL17055725 | 0.76 | KDM4E (0.60) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL12419565 | 0.75 | NPC1 (0.67) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13435542 | 0.75 | NPC1 (0.62) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1423037 | 0.74 | NPC1 (0.61) | NPC1RAB9AKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344307-A | Compound combined with alpha-synuclein and preparation method and application thereof | 江苏省原子医学研究所 | 2024-07-16 | — | — | CN | disclosed |