Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040512 | 1.00 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3492339 | 0.88 | NPC1 (0.81) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL30622710 | 0.80 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL24653524 | 0.80 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1395948 | 0.76 | GSK3B (0.55) | NPC1RAB9AKDM4EMAPTGSK3B | |
| SCHEMBL10225785 | 0.76 | NPC1 (0.60) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL17055725 | 0.76 | KDM4E (0.60) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL12419565 | 0.75 | NPC1 (0.67) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13435542 | 0.75 | NPC1 (0.62) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1423037 | 0.74 | NPC1 (0.61) | NPC1RAB9AKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344307-A | Compound combined with alpha-synuclein and preparation method and application thereof | 江苏省原子医学研究所 | 2024-07-16 | — | — | CN | disclosed |
| WO-2013007663-A1 | 2-BENZYLSULFANYL[1,3,4]-OXADIAZOLE DERIVATIVES, AND MEDICAL USE THEREOF | Technische Universität Darmstadt (DE) | 2013-01-17 | — | — | WO | disclosed |
| US-20120071469-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2012-03-22 | — | — | US | disclosed |
| US-8106042-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors | NEUROSEARCH A/S (DK) | 2012-01-31 | — | — | US | disclosed |
| US-8101598-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use | NEUROSEARCH A/S (DK) | 2012-01-24 | — | — | US | disclosed |
| US-20110105478-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-05-05 | — | — | US | disclosed |
| US-20100317654-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | ANIONA APS (DK) | 2010-12-16 | — | — | US | disclosed |
| EP-2257550-A1 | NOVEL 1,4-DIAZA-BICYCLOÝ3.2.2¨NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch A/S (DK) | 2010-12-08 | — | — | EP | disclosed |
| WO-2010130768-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-11-18 | — | — | WO | disclosed |
| US-7807667-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use | NEUROSEARCH A/S (DK) | 2010-10-05 | — | — | US | disclosed |
| EP-2032575-B1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVE AND ITS MEDICAL USE | NEUROSEARCH AS (DK) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009112460-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | WO | disclosed |
| US-20090118266-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CANADIAN IMPERIAL BANK OF COMMERCE AS AGENT | 2009-05-07 | — | — | US | disclosed |
| EP-2032575-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138038-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105478-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA3, CHRNA2, CHRNA4 | NPC1 2278/4885RAB9A 3627/4885KDM4E 2420/4885 |
| US-20090118266-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA2, CHRNA5 | NPC1 2116/4885RAB9A 3467/4885KDM4E 2451/4885 |
| US-20120071469-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA10, CHRNA3, CHRNA6 | NPC1 748/4885RAB9A 2958/4885KDM4E 2599/4885 |
| US-20100317654-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA2, CHRNA6 | NPC1 2198/4885RAB9A 3396/4885KDM4E 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.