Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733579 | 0.85 | HRH3 (0.57) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL1857662 | 0.84 | HRH3 (0.59) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL30133987 | 0.84 | HRH3 (0.47) | HRH3MAPK1HIF1AEPAS1KDM4E | |
| SCHEMBL29256706 | 0.84 | HRH3 (0.45) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL9202121 | 0.83 | CHKA (0.55) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL17075531 | 0.82 | HRH3 (0.61) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL18173335 | 0.82 | MAPK1 (0.47) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| Hydrochloric Acid SCHEMBL30583829 | 0.80 | KDM5C (0.47) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| Hydrochloric Acid SCHEMBL29250316 | 0.80 | KDM5C (0.47) | HRH3MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL6949028 | 0.80 | KDM4E (0.46) | HRH3MAPK1KMT2AHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300951-A1 | Pyrazolopyridinone Compounds | BEIGENE LTD. (KY) | 2024-09-12 | — | — | US | disclosed |
| US-20240270751-A1 | Pyrazolopyridinone Compounds | BEIGENE LTD. (KY) | 2024-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300951-A1 | Pyrazolopyridinone Compounds | NFATC1, CD4, PBK | HRH3 1784/4885MAPK1 576/4885KMT2A 2627/4885 |
| US-20240270751-A1 | Pyrazolopyridinone Compounds | NFATC1, CD4, PBK | HRH3 1784/4885MAPK1 576/4885KMT2A 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.