Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | IL6 | P05231 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464132 | 0.88 | KDM4E (0.44) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL9733579 | 0.85 | HRH3 (0.57) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL22465802 | 0.85 | KDM4E (0.44) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL1857662 | 0.84 | HRH3 (0.59) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL9202121 | 0.83 | CHKA (0.55) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL17075531 | 0.82 | HRH3 (0.61) | MAPK1HRH3NPC1RAB9AKMT2A | |
| SCHEMBL18173335 | 0.82 | MAPK1 (0.47) | KDM4EMAPK1HRH3NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL6949653 | 0.81 | F11 (0.44) | KDM4EMAPK1HRH3NPC1RAB9A | |
| SCHEMBL15033011 | 0.80 | KDM4E (0.67) | KDM4EMAPK1KMT2AALDH1A1 | |
| SCHEMBL31043166 | 0.80 | HRH3 (0.46) | KDM4EMAPK1HRH3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1087961-B1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI SYNTHELABO (FR) | 2002-08-14 | — | — | EP | disclosed |