Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.40 |
| ▸ | CCND3 | P30281 | 3/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18479402 | 0.83 | KHK (0.48) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL22414247 | 0.81 | CHRNB2 (0.47) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL25949375 | 0.81 | CHRNB2 (0.47) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL2819513 | 0.81 | CHRNB2 (0.47) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL3612506 | 0.80 | MAPT (0.46) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL2155136 | 0.80 | MAPT (0.46) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL20139207 | 0.80 | MAPT (0.46) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL25085585 | 0.79 | KHK (0.48) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL20414146 | 0.79 | MAPT (0.43) | KHKCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL27140328 | 0.79 | KHK (0.45) | KHKADRA2AADRA2BADRA2CCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665331-A1 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173219-A1 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |