Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | CASK | O14936 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30030449 | 1.00 | TGFBR1 (0.43) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL20552910 | 1.00 | TGFBR1 (0.43) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL31046955 | 0.90 | RET (0.48) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL20553303 | 0.90 | RET (0.48) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL30029909 | 0.90 | RET (0.48) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL30405239 | 0.88 | TGFBR1 (0.40) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL30405323 | 0.81 | RET (0.39) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL30405221 | 0.80 | RET (0.46) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL23150437 | 0.79 | RET (0.50) | TGFBR1RETKDRBMPR1BPIK3CD | |
| SCHEMBL20552990 | 0.78 | ESR2 (0.48) | TGFBR1PIK3CDMAP4K4ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |