Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.71 |
| ▸ | MTOR | P42345 | 13/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.70 |
| ▸ | PRKDC | P78527 | 3/20 | 0.70 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30405677 | 1.00 | TGFBR1 (0.71) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL20552950 | 1.00 | TGFBR1 (0.71) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL31046978 | 0.95 | TGFBR1 (0.72) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL30405170 | 0.95 | TGFBR1 (0.72) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL20553170 | 0.95 | TGFBR1 (0.72) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL21528079 | 0.92 | MTOR (0.67) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL30029418 | 0.92 | MTOR (0.67) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL31046949 | 0.92 | MTOR (0.67) | TGFBR1MTORHDAC1PIK3CDPIK3CG | |
| SCHEMBL23150458 | 0.88 | MTOR (0.77) | MTORHDAC1PIK3CDPIK3CGPIK3CA | |
| SCHEMBL30405232 | 0.87 | MTOR (0.68) | TGFBR1MTORHDAC1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |