SCHEMBL31056727

SCHEMBL31056727

COC(=O)c1ccc(C2CN(CC(F)F)CCN2Cc2c(OC)cc(C)c3c2ccn3C(=O)OC(C)(C)C)cc1NC(C)=O

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CFB P00751 19/20 0.38
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29324363 1.00 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL29324362 1.00 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL31056830 1.00 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL31056670 1.00 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL31056597 0.95 CFB (0.38) CFB
SCHEMBL29320356 0.95 CFB (0.38) CFB
SCHEMBL31056887 0.94 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL31056432 0.94 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL31056679 0.94 CFB (0.38) CFBALDH1A1TP53MAPTTSHR
SCHEMBL29323253 0.94 CFB (0.38) CFBALDH1A1TP53MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024148274-A1 COMPLEMENT INHIBITION APELLIS PHARMACEUTICALS, INC. (US) 2024-07-11 WO disclosed