Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYBB | P04839 | 1/20 | 0.34 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24535150 | 0.90 | GPR119 (0.36) | GPR119NR1H2PREPMEN1KMT2A | |
| SCHEMBL26686767 | 0.88 | MEN1 (0.38) | GPR119NR1H2PREPMEN1KMT2A | |
| SCHEMBL30793376 | 0.85 | USP30 (0.39) | GPR119PREPHPGD | |
| SCHEMBL25338426 | 0.84 | NR1H2 (0.43) | NR1H2PREPMEN1KMT2ACYBB | |
| SCHEMBL25336741 | 0.84 | MEN1 (0.38) | GPR119NR1H2PREPMEN1KMT2A | |
| SCHEMBL30752551 | 0.83 | GPR119 (0.37) | GPR119NR1H2PREPESR2MAPT | |
| SCHEMBL25337124 | 0.81 | KMT2A (0.36) | NR1H2PREPMEN1KMT2ACYBB | |
| SCHEMBL30793753 | 0.80 | MEN1 (0.37) | NR1H2PREPMEN1KMT2ACYBB | |
| SCHEMBL30793809 | 0.79 | MEN1 (0.36) | GPR119NR1H2PREPMEN1KMT2A | |
| SCHEMBL30793502 | 0.78 | GPR119 (0.38) | GPR119NR1H2PREPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665735-A1 | KRAS INHIBITORS | Erasca, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2025245105-A1 | KRAS INHIBITORS | ERASCA, INC. (US) | 2025-11-27 | — | — | WO | disclosed |
| WO-2024173842-A1 | KRAS INHIBITORS | ERASCA, INC. (US) | 2024-08-22 | — | — | WO | disclosed |