Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 5/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779384 | 1.00 | CHRM4 (0.62) | CHRM4LRRK2PDE10AMETTTK | |
| SCHEMBL23779378 | 0.86 | CHRM4 (0.44) | CHRM4LRRK2PDE10AMETTGFBR1 | |
| SCHEMBL31058697 | 0.86 | CHRM4 (0.44) | CHRM4LRRK2PDE10AMETTGFBR1 | |
| SCHEMBL20602407 | 0.85 | CHRM4 (0.63) | CHRM4LRRK2TTK | |
| SCHEMBL30315708 | 0.85 | CHRM4 (0.63) | CHRM4LRRK2TTK | |
| SCHEMBL30315471 | 0.85 | CHRM4 (0.70) | CHRM4LRRK2TTKKDM4EPDK2 | |
| SCHEMBL20602537 | 0.85 | CHRM4 (0.70) | CHRM4LRRK2TTKKDM4EPDK2 | |
| SCHEMBL30935814 | 0.84 | CHRM4 (0.79) | CHRM4LRRK2TTKKDM4E | |
| SCHEMBL23779284 | 0.84 | CHRM4 (0.79) | CHRM4LRRK2TTKKDM4E | |
| SCHEMBL20602323 | 0.83 | CHRM4 (0.65) | CHRM4LRRK2TTKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873467-B1 | 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME LLC (US) | 2024-08-28 | — | — | EP | claimed |