Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 1.00 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CTRC | Q99895 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001467 | 1.00 | KDR (1.00) | KDRRAF1PLK4PLK1RET | |
| SCHEMBL5727509 | 0.83 | KDR (0.71) | KDRPLK4PLK1RETEGFR | |
| SCHEMBL5727507 | 0.83 | KDR (0.71) | KDRPLK4PLK1RETEGFR | |
| SCHEMBL5988992 | 0.81 | KDR (0.68) | KDRRAF1JAK3CDK5TLK2 | |
| SCHEMBL5988086 | 0.81 | KDR (0.68) | KDRRAF1CDK5TLK2MAPT | |
| SCHEMBL5988900 | 0.79 | KDR (0.64) | KDRRAF1RETJAK3SYK | |
| SCHEMBL5374098 | 0.76 | KDR (0.61) | KDRRAF1PLK4PLK1EGFR | |
| SCHEMBL5364548 | 0.75 | KDR (0.59) | KDRPDGFRBSYKAURKANTRK1 | |
| SCHEMBL3754999 | 0.75 | KDR (0.69) | KDRPLK4PLK1RETEGFR | |
| SCHEMBL3754998 | 0.75 | KDR (0.69) | KDRPLK4PLK1RETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |