Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988992 | 0.90 | KDR (0.68) | KDRMAPTMAPK1HTTRAF1 | |
| SCHEMBL31060741 | 0.81 | KDR (1.00) | KDRMAPTHTTRAF1TLK2 | |
| SCHEMBL6001467 | 0.81 | KDR (1.00) | KDRMAPTHTTRAF1TLK2 | |
| SCHEMBL5988782 | 0.78 | KDR (0.47) | KDRMAPTMAPK1HTTTLK2 | |
| SCHEMBL5990000 | 0.76 | PDPK1 (0.53) | KDRMAPTMAPK1HTTTLK2 | |
| SCHEMBL5988900 | 0.74 | KDR (0.64) | KDRMAPTMAPK1HTTRAF1 | |
| SCHEMBL5988173 | 0.73 | RET (0.43) | KDRMAPTMAPK1HTTTLK2 | |
| SCHEMBL5374098 | 0.72 | KDR (0.61) | KDRMAPTMAPK1HTTRAF1 | |
| SCHEMBL5988934 | 0.72 | KDR (0.54) | KDRMAPTRAF1 | |
| SCHEMBL5988962 | 0.72 | KDR (0.54) | KDRMAPTMAPK1RAF1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |