Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15835577 | 1.00 | MAPK1 (0.61) | MAPK1HTTTSHRRECQLESR2 | |
| SCHEMBL29466048 | 0.83 | KDM4E (0.50) | MAPK1HTTTSHRRECQLESR2 | |
| SCHEMBL28705086 | 0.83 | KDM4E (0.50) | MAPK1HTTTSHRRECQLESR2 | |
| SCHEMBL18083403 | 0.82 | TSHR (0.50) | MAPK1HTTTSHRESR2ESR1 | |
| SCHEMBL31561665 | 0.81 | FGFR1 (0.51) | MAPK1HTTALDH1A1KDM4E | |
| SCHEMBL29466021 | 0.80 | HPGD (0.43) | MAPK1HTTESR2ESR1NOS2 | |
| SCHEMBL28694895 | 0.80 | HPGD (0.43) | MAPK1HTTESR2ESR1NOS2 | |
| SCHEMBL16054504 | 0.80 | RPS6KA5 (0.52) | MAPK1HTTUSP2ALDH1A1KDM4E | |
| SCHEMBL2309144 | 0.80 | MAPK1 (0.61) | MAPK1HTTTSHRRECQLESR2 | |
| SCHEMBL20776029 | 0.79 | FGFR1 (0.50) | MAPK1HTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4438693-A2 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2024-10-02 | — | — | EP | disclosed |
| EP-3708634-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2024-08-14 | — | — | EP | disclosed |