SCHEMBL31067700

SCHEMBL31067700

N#Cc1cccc(C(=O)CCC2CC2)n1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.40
CES1 P23141 2/20 0.40
CTSK P43235 1/20 0.38
MGLL Q99685 1/20 0.35
DRD4 P21917 2/20 0.35
BCHE P06276 2/20 0.35
ACHE P22303 2/20 0.35
CNR2 P34972 1/20 0.34
HTR1A P08908 1/20 0.34
DRD2 P14416 1/20 0.34
NCEH1 Q6PIU2 1/20 0.34
DAGLA Q9Y4D2 1/20 0.34
PRKAA2 P54646 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17064418 1.00 AHR (0.40) AHRCES1CTSKMGLLDRD4
SCHEMBL17073502 0.83 CTSK (0.38) AHRCES1CTSKMGLLDRD4
SCHEMBL25784102 0.76 CTSK (0.33) AHRCES1CTSKMGLLDRD4
SCHEMBL28719014 0.75 GSK3B (0.46) AHRCES1DAGLA
SCHEMBL9323548 0.75 AHR (0.46) AHRCES1DAGLA
SCHEMBL17064920 0.73 CTSK (0.33) CTSKMGLLDRD4
SCHEMBL18623209 0.73 CTSK (0.33) CTSKMGLLDRD4
SCHEMBL17064922 0.73 CTSK (0.33) CTSKMGLLDRD4
SCHEMBL2956687 0.73 AHR (0.49) AHRCTSK
SCHEMBL29581222 0.72 SMN1; SMN2 (0.56) CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113307772-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2024-06-28 CN disclosed