Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.84 |
| ▸ | KDR | P35968 | 14/20 | 0.80 |
| ▸ | KIT | P10721 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | GMNN | O75496 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | RAF1 | P04049 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | GLA | P06280 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | FBP1 | P09467 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | SRC | P12931 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067633 | 0.91 | KDR (0.82) | EGFRKDRKITAURKAFLT1 | |
| SCHEMBL31067630 | 0.89 | KDR (0.82) | EGFRKDRKITAURKA | |
| SCHEMBL31067576 | 0.89 | KDR (1.00) | EGFRKDRKITRAF1SRC | |
| SCHEMBL31067733 | 0.88 | KDR (0.80) | EGFRKDRKITLCKPDGFRA | |
| SCHEMBL31067695 | 0.88 | KDR (1.00) | EGFRKDRKITKDM4EMAPT | |
| SCHEMBL31067615 | 0.88 | KDR (0.80) | EGFRKDRKITAURKA | |
| SCHEMBL31067694 | 0.88 | KDR (0.83) | EGFRKDRKITFLT1 | |
| Tyrphostin Ag-1478 SCHEMBL93838 | 0.87 | EGFR (1.00) | EGFRKDRKDM4EMAPTMAPK1 | |
| Tyrphostin Ag-1478 SCHEMBL31079458 | 0.87 | EGFR (1.00) | EGFRKDRKDM4EMAPTMAPK1 | |
| Tyrphostin Ag-1478 SCHEMBL29483198 | 0.87 | EGFR (1.00) | EGFRKDRKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530175-A | PDGFR inhibitor and preparation method and application thereof | 中国药科大学 | 2024-08-23 | — | — | CN | disclosed |