Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | UGCG | Q16739 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.36 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22204175 | 0.77 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29349029 | 0.76 | NPC1 (0.41) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL31068159 | 0.76 | NPC1 (0.41) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29303343 | 0.75 | CHRM1 (0.48) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL8710756 | 0.75 | NPC1 (0.60) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29610632 | 0.74 | NPC1 (0.74) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL4150687 | 0.74 | NPC1 (0.74) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL10086556 | 0.71 | NPC1 (0.55) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL10314935 | 0.71 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL23511759 | 0.70 | TP53 (0.51) | NPC1RAB9ATP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4648853-A1 | TARGETED DEGRADATION OF VAV1 | Monte Rosa Therapeutics AG (CH) | 2025-11-19 | — | — | EP | disclosed |
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |