Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | VHL | P40337 | 1/20 | 0.31 |
| ▸ | ELOC | Q15369 | 1/20 | 0.31 |
| ▸ | ELOB | Q15370 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223432 | 1.00 | GRM5 (0.39) | GRM5MAOAMAOBCASP1CASP7 | |
| SCHEMBL29561825 | 0.88 | GRM5 (0.51) | GRM5MAOAMAOBPRKCIMAPT | |
| SCHEMBL30646100 | 0.88 | GRM5 (0.47) | GRM5MAOAMAOBPRKCIPARP1 | |
| SCHEMBL867309 | 0.88 | GRM5 (0.51) | GRM5MAOAMAOBPRKCIMAPT | |
| SCHEMBL17606422 | 0.75 | GRM5 (0.39) | GRM5MAOAMAOBCASP1CASP7 | |
| SCHEMBL12983650 | 0.75 | CYP2C19 (0.58) | GRM5CASP1CASP7HSD17B10NSD2 | |
| SCHEMBL31067757 | 0.75 | CYP2C19 (0.58) | GRM5CASP1CASP7HSD17B10NSD2 | |
| SCHEMBL16798336 | 0.75 | GRM5 (0.39) | GRM5CASP1CASP7HSD17B10CYP2C19 | |
| SCHEMBL31554167 | 0.75 | CYP2C19 (0.34) | GRM5TDP2NSD2CYP2C19 | |
| SCHEMBL23666903 | 0.73 | MAP4K1 (0.35) | GRM5MAOAMAOBTDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719394-A2 | INHIBITORS OF TYK2 | Atomwise Inc. (US) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024250010-A2 | INHIBITORS OF TYK2 | Atomwise Inc. (US) | 2024-12-05 | — | — | WO | disclosed |
| CN-118265700-A | Substituted naphthyridinone derivative, pharmaceutical composition and application thereof | 上海海雁医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |