Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561825 | 0.96 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL867309 | 0.96 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL31069650 | 0.88 | GRM5 (0.39) | GRM5MAOAMAOBPARP1ALDH1A1 | |
| SCHEMBL21223432 | 0.88 | GRM5 (0.39) | GRM5MAOAMAOBPARP1ALDH1A1 | |
| SCHEMBL8630992 | 0.77 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL930529 | 0.74 | ADRA2A (0.46) | GRM5MAOBNPSR1SMN1; SMN2 | |
| SCHEMBL23376905 | 0.73 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL23376853 | 0.73 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL23376904 | 0.73 | GRM5 (0.51) | GRM5MAOAMAOBALDH1A1NPSR1 | |
| SCHEMBL3894956 | 0.73 | CYP2C19 (0.54) | GRM5MAOAMAOBALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543437-A1 | 3-?HSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250480-A1 | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2023-12-28 | — | — | WO | disclosed |