Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | USP1 | O94782 | 2/20 | 0.49 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13300144 | 0.93 | CYP1A2 (0.58) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300086 | 0.90 | CYP1A2 (0.49) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300211 | 0.90 | CYP1A2 (0.57) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300216 | 0.90 | CYP1A2 (0.49) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300137 | 0.90 | CYP1A2 (0.51) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL3105547 | 0.89 | USP1 (0.50) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300218 | 0.88 | MEN1 (0.55) | CYP1A2CYP3A4CYP2C19CLK4MAPK1 | |
| SCHEMBL13300292 | 0.87 | METAP1 (0.53) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300119 | 0.85 | MERTK (0.51) | METAP1CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL13300139 | 0.85 | METAP1 (0.54) | METAP1CYP1A2CYP3A4CYP2C19CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2198867-A1 | Pyrimidine-based compounds useful as GSK-3 inhibitors | Vertex Pharmaceuticals, Inc. (US) | 2010-06-23 | — | — | EP | disclosed |
| EP-2198867-A1 | Pyrimidine-based compounds useful as GSK-3 inhibitors | Vertex Pharmaceuticals, Inc. (US) | 2010-06-23 | — | — | EP | disclosed |
| EP-1474147-B1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |
| EP-1474147-B1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |
| EP-1474147-A1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2004-11-10 | — | — | EP | disclosed |
| US-20030199526-A1 | Pyrimidine-based compounds useful as GSK-3 inhibitors | VERTEX PHARMACEUTICALS, INCORPORATED | 2003-10-23 | — | — | US | disclosed |
| WO-2003049739-A1 | PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS | VERTEX PHARMACEUTICALS, INC. (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199526-A1 | Pyrimidine-based compounds useful as GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | METAP1 2597/4885CYP1A2 2209/4885CYP3A4 2517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.