Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 6/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31688659 | 0.99 | ITGB3 (0.49) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL25360874 | 0.99 | ITGB3 (0.49) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL26009739 | 0.99 | ITGB3 (0.49) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL26008260 | 0.92 | ITGB3 (0.48) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL31688669 | 0.85 | HRH2 (0.46) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL31688810 | 0.85 | HRH2 (0.46) | ITGB3ITGA2BHRH2HRH1FAAH | |
| SCHEMBL25357494 | 0.83 | HRH3 (0.48) | ITGB3ITGA2BHRH2HRH1HTR2A | |
| SCHEMBL25357478 | 0.83 | HRH3 (0.48) | ITGB3ITGA2BHRH2HRH1HTR2A | |
| SCHEMBL25356954 | 0.82 | KDM4E (0.51) | SLC7A5 | |
| SCHEMBL26009757 | 0.82 | KDM4E (0.51) | SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024172166-A1 | HUMAN TRANSFERRIN RECEPTOR-BINDING PEPTIDE | ＪＣＲファーマ株式会社 | 2024-08-22 | — | — | WO | disclosed |