Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152470 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL15265663 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL15265894 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL24325925 | 0.80 | MTNR1A (0.39) | MTNR1AMTNR1BEPHX2MAPTALOX15 | |
| SCHEMBL29570685 | 0.80 | MTNR1A (0.39) | MTNR1AMTNR1BEPHX2MAPTALOX15 | |
| SCHEMBL8986731 | 0.79 | BRD4 (0.55) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL2620988 | 0.79 | BRD4 (0.55) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL9965445 | 0.79 | BRD4 (0.55) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| Hydrochloric Acid SCHEMBL8017393 | 0.78 | BRD4 (0.53) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL3825586 | 0.75 | PLAU (0.45) | MTNR1AMTNR1BEPHX2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469164-A1 | TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | disclosed |
| WO-2024169914-A1 | TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2024-08-22 | — | — | WO | disclosed |