Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392166 | 0.95 | TSHR (0.64) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1390978 | 0.91 | TSHR (0.59) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1390992 | 0.90 | MAPK1 (0.61) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1391174 | 0.89 | KMT2A (0.62) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1391224 | 0.86 | TSHR (0.55) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1390767 | 0.86 | MAPT (0.63) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1392051 | 0.82 | TSHR (0.50) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL1392162 | 0.79 | MAPT (0.63) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL5032270 | 0.73 | KCNH3 (0.59) | TSHRKCNH3MAPTMAPK1ALDH1A1 | |
| SCHEMBL6729004 | 0.72 | MAPT (0.53) | TSHRKCNH3MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231624-A2 | TRIAZINES AND RELATED COMPOUNDS HAVING ANTIVIRAL ACTIVITY, COMPOSITIONS AND METHODS THEREOF | Progenics Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009091388-A2 | TRIAZINES AND RELATED COMPOUNDS HAVING ANTIVIRAL ACTIVITY, COMPOSITIONS AND METHODS THEREOF | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | WO | disclosed |