Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107768 | 1.00 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL1545485 | 0.86 | KCNH2 (0.53) | RAB9ANPC1SMN1; SMN2TSHRGRM5 | |
| SCHEMBL5741983 | 0.84 | KCNH2 (0.51) | RAB9ANPC1SMN1; SMN2TSHRGRM5 | |
| Methane SCHEMBL5741987 | 0.83 | KCNH2 (0.50) | RAB9ANPC1SMN1; SMN2TSHRGRM5 | |
| SCHEMBL26294458 | 0.80 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4101459 | 0.80 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL24590515 | 0.77 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3108844 | 0.77 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL1544609 | 0.77 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3110806 | 0.77 | GRM5 (0.48) | RAB9ASMN1; SMN2TSHRGRM5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100273805-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | US | claimed |
| US-20100273805-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273805-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 | GRM5, GRM3, GRIK5 | RAB9A 821/4885NPC1 2401/4885SMN1; SMN2 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.