Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1761032 | 0.99 | NPC1 (0.53) | NPC1KDM4EPBKTSHRMEN1 | |
| Hydrochloric Acid SCHEMBL21640445 | 0.84 | NPC1 (0.57) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL17404960 | 0.84 | NPC1 (0.68) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL18394945 | 0.82 | NPC1 (0.63) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL8013302 | 0.82 | NPC1 (0.67) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL29541828 | 0.82 | PBK (0.45) | NPC1KDM4EPBKTSHRKMT2A | |
| SCHEMBL2654124 | 0.80 | NPC1 (0.77) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3005160 | 0.77 | KDM4E (0.56) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3005169 | 0.77 | KDM4E (0.56) | NPC1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL2606462 | 0.76 | MEN1 (0.49) | NPC1KDM4ETSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |