Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17404960 | 0.98 | NPC1 (0.68) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL2654124 | 0.91 | NPC1 (0.77) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL15199106 | 0.84 | NPC1 (0.72) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL18394945 | 0.84 | NPC1 (0.63) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL4293208 | 0.84 | SMN1; SMN2 (0.65) | NPC1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL31078433 | 0.82 | NPC1 (0.54) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL25217762 | 0.81 | NPC1 (0.64) | NPC1MEN1KMT2AKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1761032 | 0.81 | NPC1 (0.53) | NPC1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL10270561 | 0.80 | NPC1 (0.67) | NPC1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL21222595 | 0.80 | NPC1 (0.58) | NPC1MEN1KMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1098098-A | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1995-02-01 | — | — | CN | claimed |
| CN-1084619-C | Process for preparing medicine composition | WYETH JOHN & BROTHER LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| CN-1206589-A | Process for preparing medicine composition | WYETH JOHN & BROTHER LTD (GB) | 1999-02-03 | — | — | CN | disclosed |
| CN-1098098-A | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1995-02-01 | — | — | CN | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |